Based on the panel data from 283 prefecture?level cities across China from 2012 to 2022， the spatial characteristics and evolutionary process of industrial chain resilience are empirically investigated. By using the Spatial Durbin Model， the driving effects of both digital economy development and innovation factors agglomeration on industrial chain resilience have been evaluated. The study finds that both the digital economy and innovation factors agglomeration significantly promote the enhancement of urban industrial chain resilience， with this effect exhibiting heterogeneous characteristics， which remains valid after endogeneity conduction and robustness test. From the perspective of spatial spillover effects， their synergy not only promotes the resilience locally but also significantly benefits neighboring cities. From the perspective of heterogeneity， their agglomeration in eastern regions， as well as in large?and?mega cities， has a positive spatial spillover effect on neighboring cities. And analysis on agglomeration indicates that only regions with "high?level industrial synergy" exhibit positive spillover effects on neighboring cities， while such effects are not significant in other regions.