The knowledge framework left by western colonial medicine and contemporary global health governance as its continuation has been manifested as a top-down approach to disease eradication, the narrowly defined effect evaluation based on cost-benefit principles, and the neglect to structural elements behind health problems. Factors such as the rise of agricultural aid after World War II, the advancement of global health governance to the field of nutrition and agriculture, the convergence of agricultural genetically modified research and development(AGMRD) institutions and contemporary global health governance in the organizational structure, and the coverage of global health governance by the agenda guiding AGMRD, have contributed to the technological trend that AGM organisms intervene in global health issues by following this knowledge framework. However, the limitations of this knowledge framework alienate its participation in global health governance from the existing order and real needs of the living world. Therefore, the improvement of the quality of global health governance depends on the reflection and transcendence of the framework itself and the "global science" on which it is rooted.