Regional coordinated development has put forward deeper demands on regional economic structure's transformation and upgrading. Whether the strategical opportunity brought by digital economy can be seized to achieve regional economic structural transformation has become a commonly concerned hot issue in academics and government circles. Digital economy drives regional economic structural transformation mainly through quality reforming, efficiency reforming and power reforming. At present, digital economy presents the following typical factual characteristics in promoting the transformation of China's regional economic structure: On the one hand, it promotes leading industries' renewal, deeps industrial specialization, elevates economic resilience and enhances economy structures' inclusiveness; on the other hand, the digital economy gap among regions will increase the difficulty of regional economic structure's collaborative transformation. In pursuit of narrowing digital economy gap among regions, promoting the synergistic transformation of regional economic structures and achieving regional coordinated development, China's spatial economic policies should be adjusted in a targeted manner focusing on data elements' regional interoperability, digital economy's regional collaboration and digital dividends' regional sharing.