To further promote high-quality development and expand Chinese-mode modernization, the report to the 20th National Congress of the Communist Party of China(CPC) has deployed the strategy of "creating an open and globally-competitive innovation ecosystem". From the perspective of cross-regional symbiotic network, a theoretical analysis has been carried out on the construction and evolution of open innovation ecology driven by industrial two-way transfer. The results show that industrial two-way transfer powerfully supports constructing an open innovation ecology by laying material foundation, creating institutional environment and providing internal and external impetus; that, driven by such transfer, the innovation behavior evolves from linear to integrated and then to open one; and that the innovation pattern evolves from simple beneficial symbiosis to preferable beneficial one and then to mutual beneficial one. Basically, relevant guiding policies have been put forward for open innovation ecological construction driven by industrial two-way transfer from the micro, medium and macro levels.