The current comprehensive strategic anxiety of the United States towards China is the third national strategic anxiety since World War II, following those towards Soviet Union and Japan. The first strategic anxiety was based on a strategic competition with few economic intersections between the United States and the Soviet Union, in the course of which the United States unilaterally carried out economic blockade, arms race, public opinion war, and value subversion against the Soviet Union, and resorted to the power of its allies in an all-out confrontation. The second anxiety against Japan is limited to the economic field, and mainly achieved through cracking down on Japan's semiconductor industry, waging trade war, and overall forcing Japanese Yen to appreciate. The the third strategic anxiety and response measures towards China are more global and radical, involving a comprehensive strategic containment on economy, politics, military, ideology, public opinion, etc. which is an organized and systematic competition against China applying international rules led by the United-States and his global allies. In this regard, China needs to have a clear understanding on its long-term and comprehensive nature, fully absorb the experiences and lessons from the former two cases, and make full preparations to cope with the situation while firmly adhering to its own development path, and continuously consolidate its own strength to respond the uncertain challenges in the future.