In the current wave of emerging technologies， S&T ethical practices are facing unprecedented ethical challenges. In order to effectively tackle complex and ever?changing ethical issues， S&T ethics decision?makers are expected to apply systematic principles as a theoretical guidance for decision?making. Following the systemic principles， decision?makers can analyze the ethical risks and their mutual impacts in multiple fields from a global perspective， and respond to ethical challenges in a more scientific and systematic way in the process of practical decision?making， thereby enhancing the rationality and effectiveness of decision?making.