A WICS model has been applied to quantitatively analyze the content deeds of 81 academicians of both the Chinese Academy of Science and the Chinese Academy of Engineering in Hubei Province. The characteristic elements of leadership quality of leading sci-tech talents have been probed into, based on which relevant hypotheses have been put forward and regression verification has been analyzed. Subsequently, a leadership quality model of such kind of talents has been proposed with moral leadership, scientific research leadership and team leadership as the core. In addition, the specific paths to effectively improve their leadership have been explored-to improve self-cultivation to advance moral leadership, to establish innovational consciousness to advance scientific research leadership, and to strengthen communication and collaboration to advance team leadership.